Welcome to the Khalaila research group website: Our research group is investigating the role of glycosylation on protein functions, specifically the O-GlcNAc modification of cytoplasmic and nuclear protein, which is a cell nutrient sensor and have been shown to play a significant role in cell cycle and proliferation. We found that this modification is elevated in colorectal cancer and its metastatic clones. Understanding the effect of O-GlcNAcylation on cancer development and metastasis hold great promise for the development of new modalities for cancer treatments.
Additionally we are investigating the egg development process in invertebrate such as Crustacean and Spiders, specifically the yolk-protein and the interaction with its receptor mechanism, a mechanism similar to the LDL and its receptor in the human body.
We are also interested in how invertebrate eggs are protected against bacteria and parasites.